Visual and Auditory long-latency Brain Potentials in Patients with Type 2 Diabetes Mellitus

Oscar Hernando Hernández

Abstract

Purpose Diabetes mellitus type 2 (DM2) selectively affects the sensory systems causing damage to some cognitive brain processes. Since complications deteriorate the quality of life, it is imperative to find new preclinical indicators of neurodegenerative changes, identifying which parameter and sensory modality is more sensitive to the disease to monitor them directly .In this study, parameters of visual and auditory long-latency brain potentials (P200) were compared in order to determine their characteristics and its possible associations with the metabolic status of patients. Materials/methods Sensory stimuli were applied to 36 patients and 36 controls, and the latency, amplitude and the rate of rise of the P200 waves were measured .Results The amplitude of visual potentials showed an inverse relationship with Glycemia (p < 0.038, 1-tailed) and glycosylated hemoglobin (p < 0.040), while the rate of rise was lower in >10-year diabetic patients (p < 0.023). Latencies and auditory parameters were more resilient. No differences between groups were obtained. Conclusions there is evidence that DM2 produces selective effects on the P200 wave, which are dependent on the parameter and the sensory modality measured. It is suggested to use the amplitude and the rise rate of visual potentials to monitor neurological impairment in uncontrolled patients.

Keywords: Diabetes Mellitus Evoked Potentials, Auditory, Visual, P200.

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